Tbk1 dimer
WebTBK1 normally exists as a dimer, and dimerization occurs primarily through intermolecular interactions in the SDD. Additional intermolecular interactions in the KD and ULD in … WebJul 19, 2024 · DM, dimerization motif. PM, phosphorylation motif. TBM, TBK1 binding motif. (B) Sequence alignment of the region of LBDα1 from various species. The number is based on human STING. GXXXS motif is labeled as cyan bar. FIGURE 3 Figure 3 Structures of LBD domain and full-length STING in apo and ligand-bound forms.
Tbk1 dimer
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WebSep 12, 2024 · In the structure of the TBK1 dimer, the activation of TBK1 is mainly controlled by trans-autophosphorylation, in which two KDs limit the cis-autophosphorylation activity of TBK1 ( 38 ). A highly conserved PLRT/SD motif in the C-terminal tail (CTT) of STING mediates the recruitment of TBK1 by binding directly to the dimeric interface of … WebMar 28, 2013 · A crystallographic 2-fold axis runs along the long axis of the molecule and generates the TBK1 dimer ( Figure 1 C). The dimensions of the dimer are ∼110 × 133 × 80 Å and the overall trimodular architecture resembles that of the previously determined IKKβ structure ( Figure 1 E; Xu et al., 2011 ).
WebSep 12, 2024 · Extensive interactions between KD, ULD, and SDD form the dense TBK1 dimer. The KD of TBK1 consists of N-terminal and C-terminal leaflets with an active ATP … WebMay 27, 2024 · An intact TBK1 dimer undergoes K63-linked polyubiquitination on Lys30 and Lys401 , catalyzed mostly by the TNF receptor-associated factor (TRAF) family E3 ligases . Structure of the STING-TBK1 complex was recently resolved by cryogenic electron microscopy (Cyro-EM), showing that the PLPLRT/SD motif in the C-terminal tail of …
WebJun 6, 2013 · The two long continuous helices α1s and α4s contain 77 and 70 residues, respectively. The C-terminal 30 residues of helix α1s make major contributions to the TBK1 dimer formation (Figures 3A and 3B). The third helix is broken into two segments of 24 (α2s) and 31 (α3s) residues connected by a long loop of 29 residues (Figure 2B). WebJun 7, 2024 · TBK1 has three primary domains, 1) a kinase domain, 2) a ubiquitin-like domain, and 3) a scaffold dimerization domain, which are followed by a flexible C terminus domain (CTD) (Fig. 1A) (13–15).Two TBK1 monomers dimerize along their scaffold dimerization domains, while kinase activity is activated via autophosphorylation of the …
WebMar 6, 2024 · The authors find that a TBK1 dimer binds above the cGAMP-binding pocket of a STING dimer. Their model suggests that the carboxy-terminal (C-terminal) ‘tail’ region …
texas map 2022WebMay 22, 2024 · TBK1 dimer is shown by the ribbon representation coloured in green and cyan. d , Difference map of human STING CTD bound to human TBK1 contoured at 2.5 … texas map applicationWebBarbie, Eck, and colleagues describe the crystal structure of Tank-binding kinase-1 (TBK1), which reveals a dimer architecture stabilized by contacts among the kinase, ubiquitin-like, and scaffold/dimerization domains. Functional studies show that the intact dimer is required for TBK1 activation and signaling, as well as for K63-linked polyubiquitination of TBK1 on … texas map 1845WebTBK1 activity is regulated by phosphorylation on S172 within theclassical kinase activation loop.Serine-to-alanine substitution ... dimer, suggesting that the ULD and SDD serve to buttress the KD as well as to contribute additional binding surfaces that properly orient substrates (25). texas map airportsWebJan 1, 2013 · Upon stimulation by pathogen-associated inflammatory signals, TANK-binding kinase 1 (TBK1) induces type I interferon expression and modulates nuclear factor κB (NF-κB) signaling. Here, we describe the 2.4 Å-resolution crystal structure of nearly full-length TBK1 in complex with specific inhibitors ... Macromolecules texas map and countiesWebEnter the email address you signed up with and we'll email you a reset link. texas map all citiesWebOct 12, 2024 · TANK-binding kinase 1 (TBK1), a dimeric serine/threonine protein kinase, plays a critical role in multiple signaling pathways including innate immunity, autophagy … texas map 1870