Spliced xbp-1
Web15 Aug 2009 · XBP1 is a key transcription factor that regulates the mammalian unfolded protein response. Its expression is regulated by unconventional mRNA splicing that is … WebNational Center for Biotechnology Information
Spliced xbp-1
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Web22 Jul 2024 · XBP1 splicing assay by RT-qPCR. RT-qPCR was used to quantify the relative expression of the spliced version of XBP1 (XBP1s) by using specific pairs of primers for human alternatively... WebTREB5, X box binding protein 1, XBP 1, XBP1, XBP1S, XBP1S-specific, XBP2. Overview. Tested Applications; Product Information; Publications (41) Protocols; Reviews (1) ... The …
Web28 Apr 2006 · Spliced XBP-1 is a potent transcriptional activator that increases expression of a subset of UPR-related genes . The cytosolic domain of activated IRE1α binds the … WebLiver fibrosis is a major pathological feature of chronic liver disease and effective therapies are limited at present. The present study focuses on the hepatoprotective potential of L. corymbulosum against carbon tetrachloride (CCl4)-induced liver damage in rats. Analysis of Linum corymbulosum methanol extract (LCM) using high-performance liquid …
Web11 Jan 2013 · XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. Sustained activation of X-box-binding protein … Web14 Jun 2012 · Hypoxia can cause ER stress in MM cells in vivo because both solid tumors and the MM BM have been reported to be hypoxic. 37,38 Indeed, XBP1 is spliced under …
Web15 Oct 2012 · Stress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a signaling mechanism that allows cellular adaptation to ER stress by engaging pro-adaptive transcription factors and alleviating protein folding demand. One such transcription factor, X-box binding protein (XBP1), originates from the inositol …
WebXBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was … oldcastle infrastructure wilsonville orWeb19 May 2024 · Activated XBP-1 enhances DNA translation of XBP-1 itself as well as PERK, ATF4, and eukaryotic translation initiation factor 2 alpha kinase 3 (eIF2ak3) which are all important to UPR activity . XBP-1 also binds the promoter of the immunoglobulin heavy chain-binding protein (BiP) gene, an important chaperone that both aids in the UPR and is … oldcastle job reviewsWebThe clone 9D11A43 recognizes spliced XBP-1 (XBP-1s/isoform 2), which is 371 amino acids and migrates around 55 kD on the SDS-PAGE. Additional Product Notes Using this … my own eco energyWebNon-splice-specific flanking primers (upper: 50 -AAGC- mal breast tissue6 and breast cancer cell lines.7 In addition, the CAAGGGGAATGAAGT-30 , lower: 50 … oldcastle inman scWebThe results showed that both UPR (Xbp-1, its spliced variant sXbp-1, Atf-6, Chop, and Grp94) and Tlr (2, 3, 4, 7 and 9) genes were significantly upregulated in the hippocampi of rats who were ... my own drum remix with missy elliottWeb1 Mar 2005 · Isoform 2 interacts with SIRT1. Isoform 2 interacts with PIK3R1 and PIK3R2; the interactions are direct and induce translocation of XBP1 isoform 2 into the nucleus … my own duncan idahoWeb10 Apr 2024 · The tissue slices or whole-mount meninges were rinsed with PBS for 10 min and treated by blocking solution (1% BSA, 0.4% Triton X-100 and 4% goat serum in PBS) for 1 h at room temperature, followed by incubation with appropriate dilutions of primary antibodies: anti-LYVE-1 (eBioscience, ALY7, 1:200), anti-CD169 (Abcam, 3D6.112, 1:100), … my own edification