Otud6a topbp1
WebOTUD6A is upregulated in human patients with colorectal cancer. The depletion of OTUD6A leads to lower Drp1 levels and suppressed mitochondrial fission, and the affected cells are consequently less prone to tumorigenesis. Conversely, the overexpression of OTUD6A increases Drp1 levels and its protein half-life and enhances cancer cell growth. WebSubsequently, OTUD6A was recruited to the damage site, where it interacted with TopBP1 and blocked the interaction between TopBP1 and its ubiquitin E3 ligase UBR5, decreasing …
Otud6a topbp1
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WebMar 21, 2024 · OTUD6A (OTU Deubiquitinase 6A) is a Protein Coding gene. Diseases associated with OTUD6A include Junctional Epidermolysis Bullosa Non-Herlitz Type . … Web2024年6月29日，中山大学丁俊军研究团队与北京大学李程研究团队在Cell Research上发表最新研究成果。该研究首次揭示了染色质结构因子CTCF除介导经典环挤压模型调控较短距 …
WebJul 5, 2024 · 该研究发现otud6a通过调控topbp1蛋白的泛素化修饰和稳定性来参与dna损伤修复，维持细胞基因组稳定性，抑制肿瘤细胞对放化疗药物的敏感性并促进乳腺癌的发展。 … WebFeb 7, 2024 · Title: Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. …
WebNov 7, 2024 · In the germ line of resulting Topbp1 flox/+ Ngn3 Cre sons, Cre recombinase converts Topbp1 flox alleles into Topbp1 − (i.e., null) alleles. Mating these males to Topbp1 flox/flox females generates Topbp1 flox/− Ngn3 Cre sons and Topbp1 flox/+ Ngn3 Cre control brothers. Topbp1 flox and Ngn3 Cre were maintained on a C57BL/6 background. WebJun 29, 2024 · Subsequently, OTUD6A was recruited to the damage site, where it interacted with TopBP1 and blocked the interaction between TopBP1 and its ubiquitin E3 ligase …
WebPersistent TopBP1 foci transition into 53BP1 nuclear bodies (NBs) in G1 and precise temporal depletion of TopBP1 just before mitotic entry induces formation of 53BP1 NBs …
WebThe immunogen of 24486-1-AP is OTUD6A Fusion Protein expressed in E. coli. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after … ridge landscapingWebJan 8, 2024 · Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. … ridge lane rotherwickWebATM TOPBP1. Biochemical Activity. Biochemical Activity. An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. ridge lap implant crownWebMar 21, 2024 · TOPBP1 (DNA Topoisomerase II Binding Protein 1) is a Protein Coding gene. Diseases associated with TOPBP1 include Ataxia-Telangiectasia and Seckel Syndrome.Among its related pathways are Homologous DNA Pairing and Strand Exchange and Homology Directed Repair.Gene Ontology (GO) annotations related to this gene … ridge lasso sklearnWebApr 27, 2015 · Expression of ectopic TopBP1 induces shut-down of rRNA transcription and nucleolar segregation. (A) Expression of eGFP-TopBP1 was left non-induced (eGFP … ridge lasso improvement over olsWebThe Input lane is 10% input; the TOPBP1-IP lane is the immunoprecipitation with the TOPBP1 antibody (2.5 µg, VMA00940); the IgG-IP lane is the immunoprecipitation with … ridge law firmWebJun 29, 2024 · Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Sign in … ridge lap implant crown image