WebDec 1, 2005 · A better understanding of the intracellular signal transduction network that controls myocyte cell growth may suggest new therapeutic directions. mAKAP is a scaffold protein that has recently been shown to coordinate signal transduction enzymes important for cytokine-induced cardiac hypertrophy. WebIn the cardiac myocyte, the protein mAKAPβ serves as a scaffold for a large signalosome that is responsive to cAMP, calcium, hypoxia, and mitogen-activated protein kinase signaling. The main function of mAKAPβ signalosomes is to modulate stress-related gene expression regulated by the transcription factors NFATc, MEF2, and HIF-1α and type II ...
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WebPubMed WebNow we demonstrate that the mus- cle-selective A-kinase anchoring protein, mAKAP, maintains a cAMP signaling module, including PKA and the rolipram-inhibited cAMP-specific phospho- diesterase (PDE4D3) in heart tissues. discretionary waiver definition
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WebLuther. 75 Metascore. 2010 -2024. 5 Seasons. BBC One. Drama, Suspense. TVMA. Watchlist. Psychological crime drama centered on a brilliant but self-destructive detective, who has more in common ... WebMar 7, 2024 · Luther is framed by fellow detective Ian Reed (Steven Mackintosh) and forced into hiding. It marks the first irreversible consequence of Luther’s fixation with the job, and there’s a sense that... WebDec 24, 2014 · AKAPs coordinate multi-protein signaling networks that are targeted to spe … The Beta-adrenergic receptors (β-ARs) stimulation enhances contractility through protein kinase-A (PKA) substrate phosphorylation. This PKA signaling is conferred in part by PKA binding to A-kinase anchoring proteins (AKAPs). discretionary wales