WebApr 4, 2024 · EGR1 is a key player in the transcriptional control of miR-203a, and that miR-203a acts as an anti-oncogene to suppress HCC tumorigenesis by targeting HOXD3 through EGFR-related cell signaling pathways. Egr-1 upregulation is characteristic of the cardiovascular disease pathogenesis. (Review) WebApr 4, 2024 · PMID 35746681, Free PMC Article. Early growth response 1 transcription factor is essential for the pathogenic properties of human endometriotic epithelial cells. Maurya VK, et al. Reproduction, 2024 Aug 1. PMID 35679138, Primary bile acid activates Egr‑1 expression through the MAPK signaling pathway in gastric cancer.
Frontiers The Role of Early Growth Response 1 (EGR1) in Brain ...
WebOct 12, 2024 · EGR1 is an important transcription factor, which participates in cell proliferation, differentiation, invasion, and apoptosis [ 19 ]. It is widely expressed in many cell types and can be... EGR1 has been reported to inhibit tumor invasion and metastasis in many tumor types. TGF-β1 can downregulate EGR1-induced NSCLC cell EMT, and high expression of EGR1 significantly reduces EMT (64). The mechanism may be related to the regulation of SNAIL, SLUG, and E-cadherin expression by EGR1. In … See more Early growth response factor 1 (EGR1) is a member of the EGR family and is also known as EGR-1, NEFI-A, Zif268, Krox-24, and TIS85. The EGR1 gene is located in human … See more High expression of EGR1 has been observed in various tumors, in which EGR1 can play an oncogenic role, e.g., glioma, lung cancer, gastrointestinal tumors, and melanoma (22–25). As a downstream protein … See more Epithelial–mesenchymal transition (EMT) means a morphological change of epithelial cells to mesenchymal cells, which is an important mechanism of tumor cell invasion and metastasis. EGR1 contributes to tumor … See more Various authors have shown that high EGR1 expression may increase the proliferation of specific types of tumor cells by affecting the cell cycle. For example, the high expression … See more rotita christmas sweaters
EGR1 - Wikipedia
WebSep 9, 2024 · Reciprocally, CCL2 activated the CCR2-ERK-ELK1-EGR1 pathway, thus forming a positive feed-forward loop. Moreover, CCL2 in culture medium of SGC7901R cells promoted angiogenesis of Human Umbilical Vein Endothelial Cells (HUVECs). EGR1 expression was positively correlated with CCL2 and ZEB2 in clinical GC tissues, and the … WebAug 6, 2024 · Functional studies further identified that the EGR1/ADAM10 pathway is important for the inflammatory response. EGR1 intervention in vivo decreased host proinflammatory cytokine secretion and rescued the survival and tissue injury of the mouse endotoxemia model. WebEGR-1 (Early growth response protein 1) is a mammalian zinc finger transcription factor. The full human EGR1 promoter sequence contains regulatory elements including two Sp1 sites, an AP1 site, two cAMP response elements and an Egr-1 binding site, five serum response elements (SREs). straight up abilities