Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and … See more Cyclophosphamide is used to treat cancers and autoimmune diseases. It is used to quickly control the disease. Due to its toxicity, it is replaced as soon as possible by less toxic drugs. Regular and frequent laboratory … See more Like other alkylating agents, cyclophosphamide is teratogenic and contraindicated in pregnant women (pregnancy category D) except for life-threatening circumstances in the mother. Additional relative contraindications to the use of … See more The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells that have low … See more The abbreviation CP is common, although abbreviating drug names is not best practice in medicine. See more Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced nausea and vomiting See more Oral cyclophosphamide is rapidly absorbed and then converted by mixed-function oxidase enzymes (cytochrome P450 system) … See more As reported by O. M. Colvin in his study of the development of cyclophosphamide and its clinical applications, Phosphoramide mustard, one of the principal toxic … See more WebSynthesis and antitumor activity of cyclophosphamide analogues. 4. Preparation, kinetic studies, and anticancer screening of "phenylketophosphamide" and similar compounds …

Cyclophosphamide ISOPAC® 6055-19-2 - Sigma-Aldrich

WebCyclophosphamide. Synthesis and properties of this drug are described in Chapter 30. Besides being used as an alkylating agent in cancer chemotherapy, cyclophosphamide is a unique drug when used as an immunosuppressant. First, it is … WebCyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its … my phone won\u0027t make calls

Degradation Products of Cyclophosphamide Synthesis and …

WebMar 10, 2015 · Alkylating agents are a class of antineoplastic or anticancer drugs which act by inhibiting the transcription of DNA into RNA and thereby stopping the protein synthesis. Alkylating agents substitute alkyl groups for hydrogen atoms on DNA, resulting in the formation of cross links within the DNA chai … WebApr 7, 2014 · CYCLOPHOSPHAMIDE Used in the treatment of WBC cancers (AML/ALL) and Lymphoma Cell Cycle – Non specific Alkylating agent Adds Alkyl group (CnH2n+1) to DNA. 3. CYCLOPHOSPHAMIDE … WebJul 18, 2024 · Cyclophosphamide (CP A) represents a widely used anti‑cancer prodrug that is converted by liver cytochrome P450 (CYP) enzymes into the primary metabolite … my phone won\u0027t send photos