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Cyclic pifithrin-a

WebCyclic Pifithrin-α (hydrobromide) from Cayman Chemical. Be the first to write a review! Citations: Description A stable analog of PFT-α, formed by the condensation of PFT-α in solution; inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC50 = 23, 77, and 103 µM, respectively); induces autophagy in HCT116 cells and ... WebSep 16, 2005 · The small-molecule compound pifithrin-α (PFT-α) has been reported to inhibit p53 function and protect against a variety of genotoxic agents. We show here that PFT-α is unstable in tissue culture medium and is …

Cyclic pifithrin-alpha-p-nitro

WebCyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor(PFT-α) 是一种 p53 的灭活剂，可阻断 p53 依赖性转录激活和细胞凋亡。 Cyclic PFT-α 是 PFT-α 的稳定类似物。 p-nitro-Cyclic PFT-α 是一种可渗透细胞的环状 PFT-α。 在保护暴露于依托泊苷 (ED50 = 30 nM) 的皮质神经元方面，它比 ... WebPifithrin-α (PFT-α; Item No. 13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. 1 Cyclic PFT-α (Item No. 14748) is a stable analog of PFT-α. 2 p -nitro-Cyclic PFT-α is a cell-permeable form of cyclic PFT-α. 3 It is one order of magnitude more active that PFT-α in protecting cortical neurons exposed … form feed in javascript https://benevolentdynamics.com

丝状支原体山羊亚种PCR_价格-品牌-详情介绍_丁香通

Webp-nitro-Cyclic Pifithrin-α 市场价 ￥1,339.80 好评率 100% (0)条评论 商城价 登录后可查看价格 WebJan 23, 2024 · Pifithrin-α (PFT-α) is a small molecule which has been widely used as a specific inhibitor of p53 transcription activity. However, its molecular mechanism of action … WebMar 15, 2005 · All of the new analogues, Pifithrin-like and polycyclic dehydrated derivatives were assessed for their p53 inactivation potency by measuring survival of cortical neurons, whose death was induced by the DNA-damaging agent etoposide. Pifithrin-alpha like 2f as well as the cyclic dehydrated 6b analogue were found to be one log more potent p53 ... form feed meaning in java

Transcription Factor Inhibitors SCBT - Santa Cruz Biotechnology

Category:An evaluation of the ability of pifithrin-α and -β to inhibit p53 ...

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Cyclic pifithrin-a

Cyclic Pifithrin-a = 98 HPLC 511296-88-1 - Sigma-Aldrich

WebPifithrin-α (PFT-α; Item No. 13326) is a reversible inhibitor of p53-dependent transcription and apoptosis. 1 Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution. 2 It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC 50 = 23, 77, and 103 μM, respectively). 2,3 At doses … WebCyclic Pifthrin-Alpha is a cell-permeable and reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription. It is a more stable and less cytotoxic analog of the non-cyclic form of pifithrin-alpha. …

Cyclic pifithrin-a

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WebJul 16, 2004 · A, PFTα does not affect transcription at a GR saturating concentration of dexamethasone ( Dex ). Mouse fibroblast cells stably transfected with the MMTV-CAT … WebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine …

WebCyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells. Packaging 5, 10 mg in glass bottle Protect from light. Biochem/physiol Actions A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity. WebJul 1, 2008 · In this study, we used cyclic pifithrin-α, a transcriptional inhibitor of p53, to further investigate the relevance of p53 function in the response of tumor cells to …

WebJan 11, 2024 · Select the department you want to search in ... WebPifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent …

WebCyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis Authors Valentina Zuco 1 , Franco Zunino Affiliation 1 Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy. PMID: 18516295 PMCID: PMC2386543 DOI: 10.1593/neo.08262 …

WebCyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells. [ 1] Packaging 5, 10 mg in … form feed in python exampleWebBiological description. Stable, cell-permeable analog of pifithrin-α ( ab120478 ). Inhibits p53-mediated apoptosis and p53-dependent gene transcription. Prevents … different type of siamese catsWebCyclic Pifithrin-alpha is a reversible and cell-permeable inhibitor of p53, which plays a crucial role in apoptosis, angiogenesis, and genomic stability. The cyclic form is the more stable and less cytotoxic version of the molecule. It is reported to be capable of increasing the efficiency of inducing pluripotent stem cells. form feed javascriptWebPifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in … different type of shower valvesWeb以下是丝状支原体山羊亚种PCR检测试剂盒说明书的订购信息： 我司提供PCR试剂盒的类别有流感病毒、副流感病毒、呼吸道合胞病毒、冠状病毒、轮状病毒、杆菌、链球菌、热带病毒等等核酸检测试剂盒。 产品名称 丝状支原体山羊亚种PCR检测试剂盒说明书 英文名称 Mycoplasma myco form feed scannerWebKey features and details. Cell-permeable transcriptional p53 inhibitor. CAS Number: 60477-38-5. Purity: > 99%. Soluble in DMSO to 10 mM. Form / State: Solid. formfeed sawgrassdifferent type of shotguns