WebDec 13, 2002 · After stimulation with CpG or T cell help, a fraction of proliferating memory B cells acquired phenotypic markers characteristic of plasma cells, namely, loss of CD20 ( Fig. 2 A) and up-regulation of CD138, CD126, and CD38 ( 15 ). These cells also secreted IgM, IgG, and IgA at a high rate ( 14 ). WebCells that express TLR-9, which include plasmacytoid dendritic cells (PDCs) and B cells, produce Th1-like proinflammatory cytokines, interferons, and chemokines. Certain CpG motifs (CpG-A) are especially potent at activating NK cells and inducing IFN-α production by PDCs, while other motifs (CpG-B) are especially potent B cell activators.
TLR signaling in B-cell development and activation Cellular ...
WebJan 15, 2005 · One potential concern in using CpG-ODN for lymphoma is that CpG-containing sequences, including 1018 ISS, have been observed to induce proliferation of primary human B cells in vitro. 56-59 Lymphoma proliferation was not observed in vivo in the single-agent study by Link et al 55 in patients with relapsed NHL or in our study. WebJun 1, 2024 · A significant effect on antibody production was detected in B cells originating from both blood and spleen. A mix of commercially available polyclonal B cell activators, mainly CpG-ODN, can substitute the above mentioned “homemade” B cell activating cocktails (Lightwood et al., 2006; Seeber et al., 2014). The mix of exactly specified and ... house design plan and budget
JCI - A TLR9-dependent checkpoint governs B cell responses to …
WebThe CpG ODNs that induce a Th-1 response and also stimulate B cells potently belong to the B class (also known as K type), while the A class (also known as D type) are potent in activating NK cells and human plasmacytoid dendritic cells to secrete interferon-α … WebApr 13, 2024 · The B1 and B2 lineages of B cells contribute to protection from pathogens in distinct ways. The role of the DNA CpG methylome in specifying these two B-cell fates is still unclear. Here we profile ... WebCpG fostered the expansion of potent CD8 + T cells with the signature phenotype and antitumor ability via empowering a direct B-T cell interaction. Isolated B cells also … house design kitchen