Context sensitive half time calculator
WebEdit. View history. Context-sensitive half-life or context sensitive half-time is defined as the time taken for blood plasma concentration of a drug to decline by one half after an infusion designed to maintain a steady state (i.e. a constant plasma concentration) has been stopped. The "context" is the duration of infusion. WebMay 1, 2024 · The context-sensitive half-time reflects the cumulative effects of these factors. This concept is marked with lipophilic drugs like thiopental, diazepam, and … Context-Sensitive Half-Time. Next article. Beginning My Last Month Of Regional … The context-sensitive half-time reflects the cumulative effects of these factors. This …
Context sensitive half time calculator
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WebMar 20, 2010 · 32. Mar 18, 2010. #6. pgg said: Half time = half life. Both terms refer to how much time will pass until 1/2 of the substance has been cleared from the site of action (by metabolism, excretion, or redistribution). "Elimination" usually implies that the drug is gone (metabolized or excreted, never to return) but there's some ambiguity to the term. WebThe context-sensitive half-time is derived from computer modelling using known pharmacokinetic parameters. The modelled context-sensitive half-time for a 3-h …
WebThe loading doses for these subjects were 17.6, 12.0, and 6.4 µg, respectively. The context-sensitive half-times for these three individuals are depicted in figure 9. There is a remarkable increase in context-sensitive half-times from 26 min in a 40-yr-old patient to 84 min in an 80-yr-old patient. WebTherapeutic Effects:Analgesia Anesthesia Implications Potency – 5-10 times more potent than Fentanyl Context-sensitive half-time (CSHT) – for continuous infusions, Sufenta …
WebAug 16, 2003 · The 50% decrease in drug concentration after the end of administration was more predicted by the context-sensitive half-time than by the elimination half-life. By computer simulations of sufentanil decay Shafer et al [ 18 ]. calculated that a 50% decrease in the effect-site concentration would take 0.8 h after a 10 h infusion. WebJul 5, 2014 · Half-life and context-sensitive half-life; Edward T. Gilbert-Kawai, University College London, Marc D. Wittenberg, University College London; Book: Essential …
WebMar 22, 2012 · Context-Sensitive Half-Time (cont.) • Alfentanil – studied for ambulatory techniques • Elimination half – life: 111 min. • Small distribution volume – not significant in plasma decay after infusion • Sufentanil – elimin. half – life: 577 min. • Less context-sensitive half-time (for infusions up to 8 hours); large volume of ...
WebUsing pharmacokinetic-pharmacodynamic models, computer simulations based on changes in the effect site opioid concentration or context-sensitive half-times seem to be … r19 3-1 syllabus jntukWebContext-sensitive half-time provides more useful information under these circumstances. If a drug is given as a constant rate infusion, steady-state concentration will only be achieved after four to five half-lives. Partial pressure largely determines the behaviour of … haval jolion city automaticWebAfter the infusion is discontinued, the time for the concentration to decrease by 50%(the context-sensitive half-life) increases from 1.5 h after a 12-hour infusion to 4.2 h after a 72-hour infusion. Based on Table 5 , to maintain a sedation score of 5, the midazolam infusion at arrival in the surgical ICU should be started at a rate of 3 mg/h. haval jolion clubWebAug 16, 2003 · The 50% decrease in drug concentration after the end of administration was more predicted by the context-sensitive half-time than by the elimination half-life. By … qwerty linkin park albumWebSep 13, 2012 · The context-sensitive half-time is the time required for blood or plasma concentrations of a drug to decrease by 50% after discontinuation of drug administration. The context-sensitive half-time often cannot be predicted by the elimination half-life (a measure of the time needed for actual drug metabolism or elimination) since it also … r1895 pistolWebApr 2, 2024 · The context sensitive half time (T1/2) of dexmedetomidine can range from 4 min after a 10-min infusion . Context sensitive time half time (T1/2) can be over 4 h after a prolonged 8-h infusion. Clearance of dexmedetomidine matures with age reaching maturity at 1 year of age and is reduced by 27% after a cardiac surgery . … haval jolion 2022 chileWebMay 13, 2015 · Understanding methadone half-life allows clinicians to prescribe the proper dosage of the drug to individuals recovering from opioid addiction. SAMHSA states, “Methadone is a long-acting medication with … haval jolion demo